Amplify lowers physical resistance by 100%. Decrepify lowers physical resistance, damage and speed by 50%. I use decrep for most Act bosses and when I'm noticing some especially nasty boss pack is picking my skeletons apart (extra strong fanaticism comes to mind).

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Corpse Explosion is one of the best direct damage skills at the Necromancer's disposal. It deals massive splash damage and scales up very well with Nightmare and Hell difficulties, as its damage is based on the monster's base Life before death (but does not increase with skill level). Decrepify combines the effects of Amplify Damage and Weaken, and also slows opponents as though they were chilled. Damage, speed, and physical resistance are all reduced by 50%. Decrepify can therefore decrease the damage output of enemies by slowing their attack (although it does not slow the actual speed of their projectiles). Sep 15, 2005  Both Amplify Damage and Decrepify can break physical immunity. Mass effect 3 mod tool. Due to the 4/5th penalty, Amp Damage does -20% physical resistance vs. Physical immuns, whereas Decrepify does.